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They actively disrupt the stoichiometry of photosynthetic proteins, degrade PSII, and change the redox state of the plastoquinone pool, resulting in the excessive production and accumulation of ROS, which eventually triggers a cell death that resembles the effector-triggered HR that limits the growth of pathogens 17,23,24,59,60,61

Additional high-quality research with long follow-up is required to refine indications, efficacy and safety profile

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However, a sex-specific effect was observed, with reduced cancer incidence and mortality in men but not in women, potentially linked to lower baseline antioxidant status in men, particularly -carotene levels (347)